The penalties depend on the type of drug or substance, the amount you have, and whether you’re also dealing or producing it. sell, deal or share drugs (also called ‘supplying’ them).Essentials of Foye’s principles of medicinal chemistry.You can get a fine or prison sentence if you: Lemke TL, Zito SW, Roche VF, Williams DA. Studies of the Natriuresis of Hydroxyamphetamine and on Its Mechanism of Action. Q.7 The drug Hydroxyamphetamine is mainly used for the diagnosis of?įor More Standard and Quality Question Bank you can Join Our Test Series Programme for GPAT, NIPER JEE, Pharmacist Recruitment Exam, Drug Inspector Recruitment Exams, PhD Entrance Exam for Pharmacy Q.6 Number of chiral centers present in the structure of Hydroxyamphetamine? The hydroxyl substituted carbon must be in the S configuration for the maximal direct activity.Q.5 Correct sequence for True and False for the given statements related with the SAR of drug…. Q.4 Hydroxyamphetamine causes release of………… which results in ……….?ĭ) acetycholine, increase in blood pressure Q.3 Match the following with correct classifications of the drugs. Q.2 Physical appearance of Hydroxyamphetamine is?ĭ) Yelllow oily liquid at room temperature Q.1 ”4-(2-aminopropyl)phenol” is the IUPAC nomenclature of which drug? For the diagnosis of Horner’s syndrome.for widening of the of the pupil during any inflammatory conditions.On reaction with 40% HBr, hydroxyamphetamine is produced. On reaction with an amide, an unstable compound is produces which on treatment with HCl produces 1-(4-methoxyphenyl)propan-2-amine. The latter compound in presence of iron and HCl gives 1-(4-methoxyphenyl)propan-2-one. 4-methoxybenzaldehyde and nitroethane reacts together in presence of primary amine to give 1-methoxy-4-((Z)-2-nitroprop-1-enyl)benzene. If phenyl group has no phenolic substituent then it may act directly or indirectly. And if only one group is present then it is preferred at 4’ position to retain the beta 2 At least one of the groups is required which can form hydrogen bonds.3’, 5’-dihydroxy compounds are orally active.3’,4’-dihydroxy substituted benzene ring has poor oral activity.The additional methyl group makes the drug more selective for the alpha 2.Erythrostero isomers have maximal activity.Ethyl group can eliminate the alpha activity of the drug.Arylalkyl group can provide beta selectivity, increased cell penetration and increased lipophillicity for the longer duration of action.N-substituent provides selectivity for different receptors.Large lipophillic groups can afford compounds with alpha blocking activity.Alpha agonist activity decreases when R 1 is larger than methyl, and went negligible when R 1 is isopropyl.Activity of both alpha and beta receptors is maximum when R 1 is methyl group.When R 1 is increased in size, activity of alpha receptors decreases and activity of the beta receptors increases.The hydroxyl substituted carbon must be in the R configuration for the maximal direct activity.Primary or secondary aliphatic amine separated by two carbons from a substituted benzene ring is essential for the high agonist activity.The SAR of Adrenergic agonist can be discussed as follows: Hydroxyamphetamine causes release of norepinephrine from adrenergic nerve. Hydroxyamphetamine is an indirect acting sympathomimetic amine drug having adrenergic properties.
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